Yes, xGen UDI-UMI Adapters are available methylated as xGen Methyl UDI-UMI Adapters. Bisulfite conversion can be carried out after ligation, but before library amplification.
It is important to note that strand-specific libraries constructed using xGen Methyl UDI-UMI Adapters have the insert strandedness flipped (i.e., to the opposite strand) compared to standard TruSeq™-Compatible Full-length Adapters.This strand flip must be accounted for during data analysis for strand-specific applications, such as Methyl-Seq.
TruSeq is a trademark of Illumina, Inc. and is used with permission.
*RUO—For research use only. Not for use in diagnostic procedures. Unless otherwise agreed to in writing, IDT does not intend for these products to be used in clinical applications and does not warrant their fitness or suitability for any clinical diagnostic use. Purchaser is solely responsible for all decisions regarding the use of these products and any associated regulatory or legal obligations.