Association for Molecular Pathology (AMP) 2024 Annual Meeting and Expo

During the AMP 2024 Annual Meeting and Expo, we showcased some of our many new solutions, products, and enhancements including:

Cancer research solutions to empower confident insights

Archer™ NGS Assay solutions

• Comprehensive genomic profiling (CGP) solutions for solid tumor research, now with modular HRD assessment, streamlined workflows with library prep automation capabilities and tertiary analysis from Molecular Health (MH Guide CAS).
• Blood cancer DNA and RNA research solutions that help your lab to detect more, including novel fusions and structural variants, with streamlined automatable workflows and tertiary analysis.
• Customizable, modular panels—add to any of our functionally-tested designs or create a new panel that fits your exact target requirements.

xGen™ NGS components

• xGen Minimal Residual Disease (MRD) offering a complete research sample preparation workflow including custom MRD hybridization capture panels delivered quickly and affordably.
• xGen cfDNA & FFPE DNA Library Prep Kit v2 empowers you with highly complex variant identification from degraded and low-input research samples.
• xGen Methyl-sequencing utilizing Adaptase™ technology efficiently captures bisulfite-converted ssDNA molecules into library molecules for epigenetic research studies—resulting in uniform and comprehensive genome coverage.

Missed us at the AMP 2024 Annual Meeting and Expo?

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Corporate workshops—Wednesday, Nov 20, 2024 (recordings coming soon):

IDT is excited to showcase how we are empowering researchers in the cancer research space by offering configurable NGS solutions and customizable workflow components to generate confident insights.

Scoring the GOAL: The Genomics Organization for Academic Laboratories

Location: Room 119 & 120, Level 1
9:00–9:50 am PST

The GOAL (Genomics Organization for Academic Laboratories) Consortium unites academic researchers, institutions, and industry partners to advance genomics research by making technologies more accessible and affordable. Through its collaboration with Integrated DNA Technologies (IDT), the Consortium reduces barriers to advanced research, enabling academic labs to conduct high-quality genomics studies.

Speakers:

• Andrew Nelson, MD, PhD—University of Minnesota
• Dara L. Aisner, MD, PhD—University of Colorado

The importance of allele-specific copy number analysis in characterizing response to synthetic lethal agents

Location: Room 119 & 120, Level 1
10:00–10:50 am PST

Allele-specific copy number analysis (ASCNA) is critical to define the extent of tumor suppressor loss of function (LOF) and contextualize the clinical response to synthetic lethal (SL) agents. Targeting tumor suppressors through SL is poised to usher in a new wave of precision oncology, but there remains a need for assays that provide reliable ASCNA. Learn how Repare Therapeutics developed an Archer technology-based NGS assay designed to perform retrospective ASCNA and identify biallelic LOF in genes predicted to sensitize to an investigational SL agent. Hear how their post-hoc analysis demonstrated the potential of biallelic LOF as a relevant biomarker in patients with solid tumors treated with an SL agent.

Speaker:

• Ian Silverman, PhD—Director of Bioinformatics, Repare Therapeutics

Posters

Friday, Nov 22nd, 9:15–10:15 am PST

• Poster #ST140: Small Panel Detection of Double Strand Break Repair Pathways
  Devin Tauber, Ryan Rogge

  Download digital copy

Saturday, Nov 23rd, 9:15–10:15 am PST

• Poster #TT031: Demonstration of FUSIONPlex™ and VARIANTPlex™ Concordance Across Multiple Sequencing Platforms
  Michael Washburn, Allison Hadjis, Christine Troutman, David Knupp, Dhruti Legare, Paula Kalavakur, Luke Hartje

  Download digital copy

• Poster # G011: Automating Archer’s FUSIONPlex™-HT and VARIANTPlex™-HT Library Prep Workflows on Hamilton Microlab STAR Liquid Handlers for High-Throughput Next-Generation Sequencing
  Cameron Picard, Callum Taylor, Dhruti Legare

  Download digital copy

• Poster #I037: Tumor Only Allele Specific Copy Number Calling with a Targeted Next-Generation Sequencing Panel
  Allison Hadjis, Taylor R. Patterson, Mark Rogers, Laura Johnson, Trent Fridey, David McConnell

  Download digital copy

• Poster #ST105: HRD Classification by ASCN Diversity and Indel Repair Signatures with Anchored Multiplex PCR and Next Generation Sequencing
  Taylor R. Patterson, Devin Tauber, Allison Hadjis, Ryan Rogge, Mark Rogers, Laura Johnson, Brent Lutz

  Download digital copy

Other happenings

Live demonstrations at booth #810 

Taking insights to research action—Molecular Health MH Guide CAS tertiary analysis platform demo
Location: Booth #810
Time: Thursday, Nov 21, 3:30-3:50 PM PST  & Friday, Nov 22, 2:45-3:05 PM PST
Learn how MH Guide CAS from IDT’s partner Molecular Health can increase your productivity and simplify your molecular tumor profiling workflow, stop by booth #810 for our demo.

Want to learn more about tertiary analysis with MH Guide CAS? Get started.